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insect gap junctions diagram

insect gap junctions diagram Functions of gap junctions listed: Transporting small molecules and ions (< 40 Å), Growth and Development (via intercellular signaling), Immunity (mediating cellular immunity responses and transmission of inflammatory responses), Organogenesis & Organ functioning (via paracrine signaling), Chemical and Electrical coupling of cells, Detoxification of Xenobiotics (elimination of toxic substances from cells), Maintenance of gonads and gametogenesis (maturation of gametes), Embryogenesis. Avenues for disrupting insect homeostasis listed: Impaired Growth and Development, Inhibited GJIC & tumor formation, Disrupted Immunity, Chemically and Electrically uncoupled cells, Nutrient deprived cells, Malformed organs, Dying cells due to accumulation of toxicant, Sterile and malformed gonads.

Gap junctions are structures that interconnect the cytoplasm of adjacent cells. In insects, they offer promise as a target for new insecticides that can control agricultural pests and insects that spread human diseases. This diagram shows selected functions of gap junctions (left), and potential avenues for disrupting insect homeostasis by targeting gap junctions (right). Inx = innexins; GJ = gap junction. (Image originally published in Sharma et al 2022, Annals of the Entomological Society of America)

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